OXYGEN INDUCED RETINOPATHY: THE KITTEN MODEL RE–EXAMINED
نویسندگان
چکیده
منابع مشابه
Revisiting the mouse model of oxygen-induced retinopathy
Abnormal blood vessel growth in the retina is a hallmark of many retinal diseases, such as retinopathy of prematurity (ROP), proliferative diabetic retinopathy, and the wet form of age-related macular degeneration. In particular, ROP has been an important health concern for physicians since the advent of routine supplemental oxygen therapy for premature neonates more than 70 years ago. Since th...
متن کاملVaso-obliteration in the canine model of oxygen-induced retinopathy.
PURPOSE To quantify the acute constrictive response of developing retinal blood vessels to hyperoxia and to examine the vaso-obliterative phase of sustained oxygen breathing in the neonatal dog model of retinopathy of prematurity. METHODS Seven littermates were used to examine the acute constrictive response of the developing retinal vessels to hyperoxia (30 minutes to 96 hours of 100% oxygen...
متن کاملOxygen-induced retinopathy in the mouse.
PURPOSE To develop oxygen-induced retinopathy in the mouse with reproducible and quantifiable proliferative retinal neovascularization suitable for examining pathogenesis and therapeutic intervention for retinal neovascularization in retinopathy of prematurity (ROP) and other vasculopathologies. METHODS One-week-old C57BL/6J mice were exposed to 75% oxygen for 5 days and then to room air. A n...
متن کاملThe neurovascular relation in oxygen-induced retinopathy
PURPOSE Longitudinal studies in rat models of retinopathy of prematurity (ROP) have demonstrated that abnormalities of retinal vasculature and function change hand-in-hand. In the developing retina, vascular and neural structures are under cooperative molecular control. In this study of rats with oxygen-induced retinopathy (OIR) models of ROP, mRNA expression of vascular endothelial growth fact...
متن کاملInner retinal oxygen metabolism in the 50/10 oxygen-induced retinopathy model.
Retinopathy of prematurity (ROP) represents a major cause of childhood vision loss worldwide. The 50/10 oxygen-induced retinopathy (OIR) model mimics the findings of ROP, including peripheral vascular attenuation and neovascularization. The oxygen metabolism of the inner retina has not been previously explored in this model. Using visible-light optical coherence tomography (vis-OCT), we measure...
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ژورنال
عنوان ژورنال: Australian and New Zealand Journal of Ophthalmology
سال: 1982
ISSN: 0814-9763,1440-1606
DOI: 10.1111/j.1442-9071.1982.tb01621.x